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How Long Does Simparica Trio Last?

If you are new to administering Simparica Trio to your dog(s), one of the first questions you will likely have is how long it will last.

Maybe you are yet to offer the first dose; perhaps you haven’t even bought the medication yet.

Either way: understanding this is crucial to ensuring your dog remains protected from fleas, tickets, heartworm, or other intestinal parasites.

You don’t want to get it wrong!

So, today, I’d like to share with you the timeline and schedule that is optimal.

This will ensure your dog has the defense they need and you don’t go through this expensive medication too fast or risk overdose.

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How Long Does Simparica Trio Last?

Simparica Trio lasts up to 35 days/5 weeks from the day it has been administered (one tablet at the appropriate dosage/strength for your dog’s size).

Now you may be probably wondering why it’s 35 days.

It’s been designed this way.

Simparica’s effects taper off by day 35, providing continuous protection in the meantime.  

As these tablets are designed to be given once per month, you essentially get a 5-day margin of error should you forget to give the next dose in time. 

This all means your dog should remain protected, all under the minimum dose required to prove effective. 

How Long Will A Packet Of Simparico Trio Last?

The typical packet of Simparico Trio, contacting six tablets, will last you six months, assuming you administer one tablet per month, which is the recommended dosage schedule.

How Often To Give Simparico Trio

Consistency is key when it comes to administering Simparica Triod. For maintaining unbroken protection against fleas, ticks, heartworm disease, and intestinal worms, you should administer one tablet to your dog every 30 days.

It’s important to note that this medication is a year-round treatment, not just a seasonal one.

Regular administration, even in colder months when parasites seem less active, ensures that your dog stays safeguarded from potential infestations and diseases.

Don’t forget to keep track of the dosage dates.

If a dose is missed, give it as soon as you remember unless it’s near the time for the next dose.

In that case, simply resume the regular schedule and skip the missed dose.

Always consult with your veterinarian for specific dosing instructions tailored to your dog’s health needs.

You may also be interested in: How Does Simparica Trio Work?

What Happens If You Miss A Month of Simparica?

Missing a month of Simparica Trio can leave your dog vulnerable to parasitic infestations, including fleas, ticks, and worms. These pests can cause a range of health issues from skin irritations and allergies to more severe conditions like heartworm disease and intestinal worm infections.

Furthermore, certain parasites, like ticks, can transmit additional diseases that can affect both pets and humans, amplifying the potential risk.

If you realize you’ve missed a dose, give it to your dog as soon as you remember, unless it’s close to the time of the next dose.

If that’s the case, simply skip the missed dose and resume your usual schedule.

Always remember to keep your veterinarian in the loop regarding missed doses or any changes in your dog’s health.

It’s better to be proactive in these situations, as they are well-equipped to provide advice tailored to your dog’s needs.

In the future, consider setting reminders on your phone or marking your calendar to ensure consistent, timely administration of Simparica Trio.

Does Simparico Trio Expire?

Simparica Trio does expire 30 months from the date of manufacture. This date will be clearly specified on the product packaging.

Equally, to maintain its effectiveness, storage conditions are also crucial.

Simparica Trio should be stored at a temperature below 30 °C (or 86 °F). Too much heat can impact the integrity and effectiveness of the medication.

So, if you have tablets stored away, always check the expiration date on the package before administering the medication to your dog.

Using expired medication could potentially risk your dog’s health as it might not provide the intended protection against parasites.

If you discover that your Simparica Trio has expired, discard it safely and obtain a new prescription from your veterinarian.


Simparica Trio is a monthly medication.

That’s how you need to see it and use it.

And while a packet of tablets is on the expensive side, it will last you six months.


Does Simparica last longer than a month?

Simparica lasts longer than a month, but only by a few days (5 extra days).

Do dogs need Simparica Trio every month?

Dogs need Simparica Trio every month to ensure they remain fully protected from fleas and ticks. Though Simparico Trio can be used as a once-off to combat heartworm.

Can I give Simparica Trio every other month?

It is best to give Simparico Trio every month to ensure continuous protection. Otherwise, your dog will be unprotected for 25 days once the dosage tapers off.

How Long Does Simparica Trio Stay In A Dog’s System?

Simparica Trio will typically remain in a dog’s system for 35 days, on average. Note this timeframe may differ depending on the dog; their age, weight, size, and breed.